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The situation changed in the late 1980s with the advent of the so-called soft ionization techniques of electrospray ionization (ESI) (Fenn et al., 1989) and matrix-assisted laser desorption/ionization (MALDI) (Clarke, 2019)

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Genetic and/or Nutritional Factor-Mediated Hyperhomocysteinemia and Incidence of Cardiovascular Disease In keeping with the occurrence of three major mechanisms leading to moderate hyperhomocysteinemia, Graham et al (1997) distinguish three main types of hyperhomocysteinemia using the methionine-loading test

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